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In Vivo proton spectroscopy and spectroscopic imaging of {1‐ 13 C}‐g1ucose and its metabolic products
Author(s) -
Van Zijl Peter C. M.,
Scott Chesnick A.,
Despres D.,
Moonen Chrit T. W.,
RhizCabello J.,
Van Gelderen P.
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910300504
Subject(s) - glutamine , heteronuclear molecule , nuclear magnetic resonance , proton , spectroscopy , chemistry , glutamate receptor , nuclear magnetic resonance spectroscopy , in vivo , biochemistry , biology , amino acid , physics , receptor , microbiology and biotechnology , quantum mechanics
Metaibolism of {1− 13 C}‐glucose was studied in situ in cat brain usinig gradient‐enhanced proton‐detected heteronuclear spectroscopy. Proton detection of {1− 13 C}‐glucose, {3− 13 C}−lactaite, 4−{ 13 C}‐glutamine, 4−{ 13 C}‐glutamate and the combined signals 2−{ 13 C}‐glutamate/glutamine and 3−( 13 C}‐glutamate/glutamine was achieved, despite the fact that some of the associated proton resonances are close to the water signal. Two‐dimensional { 1 H‐ 13 C}‐spectra demonstrate the possibility of in situ spectral assignment with 1 H sensitivity and 13 C resolution. Spectroscopic images of glucose and its metabolic products were also acquired, showing the possibility to study spatial dependence of metabolism.