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Measurement of the extraction efficiency and distribution volume for Gd‐DTPA in normal and diseased canine myocardium
Author(s) -
Tong Chun Y.,
Prato Frank S.,
Wisenberg Gerald,
Lee Ting Y.,
Carroll Edwin,
Sandler David,
Wills Jane,
Drost Dick
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910300310
Subject(s) - in vivo , occlusion , bolus (digestion) , artery , distribution (mathematics) , chemistry , coronary occlusion , cardiology , medicine , mathematics , mathematical analysis , microbiology and biotechnology , biology
We have previously shown that the myocardial Gd‐DTPA concentration ([Gd‐DTPA] t ( t )) after a bolus injection of Gd‐DTPA can be predicted by the Modified Kety Equation (MKE). If [Gd‐DTPA] t ( t ) can be determined by MRI and the data fit to the MICE, then the distribution volume (λ) of Gd‐DTPA and the myocardial flow (F) times the extraction efficiency (E), i.e., the FE product, can be determined. Therefore F can only be quantified if E is known. We measured the global E in vivo in normal canine myocardium, and measured E and λ, in vitro , locally in normal, acute ischemic (n = 5; coronary artery occlusion < 4 h), infarcted (n = 4; coronary artery occlusion, 6 days) and reperfused (n = 4; coronary artery occlusion 2 h, and reperfusion 2 h and 6 days) myocardium. Results indicate that E differs with F and with individuals and consequently, F cannot be quantified using the MKE unless the local E is also determined in vivo .