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Techniques for the measurement of the local myocardial extraction efficiency for inert diffusible contrast agents such as gadopentate dimeglumine
Author(s) -
Tong Chun Y.,
Prato Frank S.,
Wisenberg Gerald,
Lee Ting Y.,
Carroll Edwin,
Sandler Daivid,
Wills Jane
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910300309
Subject(s) - contrast (vision) , inert , extraction (chemistry) , nuclear magnetic resonance , chemistry , nuclear medicine , computer science , chromatography , medicine , artificial intelligence , physics , organic chemistry
We have previously shown that the concentration of Gd‐DTPA as, a function of time ([Gd‐DTPA] t ( t )) in the myocardium following an intravenous bolus injection of Gd‐DTPA can be moldered using the Modified Kety Equation. Fitting this model to measurements of [Gd‐DTPA] t ( t ) in a region of myocardium would allow the determination of myocardial distribution volume (λ) and the product of flow ( F ) and extraction efficiency ( E ), i.e., FE. Thus, to measure F ,E must be known. We describe here techniques developed to measure local values of E in normal and diseased myocardium. These techniques are valid for any inert diffusible MR contrast agent.