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Lactate imaging of the human brain at 1.5 T using a double‐quantum filter
Author(s) -
De Graaf A. A.,
Luyten P. R.,
Den Hollander J. A.,
Heindel W.,
Bovée W. M. M. J.
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910300212
Subject(s) - signal (programming language) , nuclear magnetic resonance , quantum , chemistry , physics , computer science , quantum mechanics , programming language
The use of a double‐quantum filtered 1 H NMR spectroscopic imaging technique is described to detect the spatial distribution of lactate in the human brain. In two patients the feasibility of this technique is shown and compared with existing single‐quantum spectroscopic imaging and single voxel techniques. Singles lice double‐quantum fitered lactate images were obtained showing the lactate distribution over the entire slice in the brain. The lipid signal suppression was sufficient for the unambiguous detection of lactate. The signal loss of the lactate signal due to the incorporation of the double‐quantum filter was 50–70% relative to the single‐quantum signal.