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In Vivo localized proton NMR spectroscopy of silicone
Author(s) -
Pfleiderer Bettina,
Ackerman Jerome L.,
Garrido Leoncio
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910300202
Subject(s) - silicone , in vivo , silicone oil , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , materials science , spectroscopy , chemistry , biomedical engineering , medicine , composite material , biology , physics , microbiology and biotechnology , quantum mechanics
1 H NMR localized spectroscopy (STEAM) can assess unambiguously the presence of free chemically unchanged silicone in animal tissue after injection of silicone oil. Although the signal—to—noise ratio obtained in 1 H imaging is sufficient to detect the distribution of relatively large amounts of silicone in vivo , the specificity of silicone detection can be improved by using 1 H localized spectroscopy techniques. The sensitivity of the STEAM experiments is sufficient to detect silicone at a concentration of 0.5% in a voxel of 27 mm 3 . Preliminary results from rats with silicone gel—filled implants show no detectable amounts of silicone in sites such as lymph nodes, the liver or the spleen, 3 or 6 months after implantation.