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On the treatment of the transient response of a heterogeneous spin system to selective RF saturation
Author(s) -
Yeung Hong N.
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910300124
Subject(s) - saturation (graph theory) , citation , transient (computer programming) , center (category theory) , nuclear magnetic resonance , physics , computer science , medicine , philosophy , library science , chemistry , mathematics , combinatorics , crystallography , operating system
For the past few years since the discovery of magnetization transfer contrast (MTC) (1-3), it has been common practice to use the model by Forsen and Hoffman (4, 5) to interpret their experimental results (1, 2, 6) in tissues or tissue-like materials. Before we can accept this model for such a purpose, it is important to question its validity. Forsen and Hoffman’s model (FHM) was originally conceived for saturation transfer of chemical systems with protons in two different environments undergoing chemical exchange. It is therefore valid in their case to assume that the protons pertaining to one of these spectral lines can be completely saturated by frequency-selective RF irradiation. One of the consequences of this assumption is that the apparent longitudinal relaxation rate for a binary system under this kind of RF irradiation is given by