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Study of ischemic myocardial buffering capacity in perfused rat heart through rapidly interleaved 1 H and 31 P MRS measurements
Author(s) -
Schussheim Adam E.,
Radda George K.
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910300117
Subject(s) - ischemia , intracellular , myocardial ischemia , intracellular ph , chemistry , medicine , cardiology , biochemistry
We present a method for the direct correlation of quantitative changes in lactate concentration and intracellular pH during global ischemia in the perfused rat heart using rapidly interleaved 31 P MRS and water‐suppressed 1 H MRS acquisitions. The ischemic myocardial buffering capacity was determined and found to be consistent with previous experimentation.