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Quantification of tissue plasma volume in the rat by contrast‐enhanced magnetic resonance imaging
Author(s) -
Kuwatsuru Ryohei,
Shames David M.,
Mühler Andreas,
Mintorovitch Jan,
Vexler Vladimir,
Mann Jeffry S.,
Cohn Frederic,
Price David,
Huberty John,
Brasch Robert C.
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910300112
Subject(s) - magnetic resonance imaging , contrast (vision) , nuclear magnetic resonance , volume (thermodynamics) , plasma volume , plasma , physics , medicine , radiology , optics , nuclear physics , quantum mechanics
Magnetic resonance imaging enhanced with a macromolecular contrast medium (MMCM), albumin‐Gd‐DTPA, was used to estimate the plasma volume in vivo in the myocardium, lung, liver, and skeletal muscle of 10 normal rats. The plasma volumes of the same tissues in a parallel group of six rats were estimated in vitro by a conventional radioisotopic technique ( 111 In‐transferrin). Plasma volumes of myocardium, lung, liver, and skeletal muscle estimated by the MR technique (μl plas. ia cc‐ 1 of tissue) were 101,109,163, and 11.0, respectively, while plasma volumes measured by the In‐transferrin radioisotope technique (mg plasma g‐ 1 of tissue) were 78.6, 215,143, and 11‐2, respectively. Assuming a ratio of densities of aerated lung to blood of 0.45 and of other tissues to blood of 1.0, correlation between the methods was excellent (R 2 = 0.99) indicating that MR imaging enhanced with MMCM permits reliable in vivo estimation of tissue plasma volume in the rat.