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Localized detection of glioma glycolysis using edited 1 H MRS
Author(s) -
Schupp Daniel G.,
Merkle Hellmut,
Ellermann Jutta M.,
Ke Yong,
Garwood Michael
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910300105
Subject(s) - homonuclear molecule , nuclear magnetic resonance , glycolysis , glioma , adiabatic process , pulse sequence , chemistry , pulse (music) , in vivo , anaerobic glycolysis , analytical chemistry (journal) , metabolism , physics , biochemistry , medicine , biology , optics , chromatography , cancer research , molecule , microbiology and biotechnology , organic chemistry , detector , thermodynamics
In vivo 1 H MRS can be used to detect and quantify the lactate resonance at 1.3 ppm provided that overlapping lipid resonances are eliminated. A homonuclear spectral editing method was developed to acquire uncontaminated 1 H spectra of lactate with adiabatic pulses. An advantage of the adiabatic pulse sequence is the ability to induce uniform flip angles and to maximize sensitivity in applications employing surface coil transmitters which produce highly inhomogeneous B 1 . Glycolytic activity in an intracerebral C6 glioma in rats was monitored by using adiabatic editing sequences to observe [3‐ 13 C]lactate produced from infused [1‐ 13 C]glucose. Acute hyperglycemia (serum glucose >22 m M , n = 10) had no significant effect ( P = 0.08) on the total ([ 12 C]+ [ 13 C]) tumor lactate signal intensity.