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In vivo degradation of silicones
Author(s) -
Garrido Leoncio,
Pfleiderer Bettina,
Papisov Mikhail,
Ackerman Jerome L.
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910290620
Subject(s) - silicone , silicon , in vivo , degradation (telecommunications) , nuclear magnetic resonance spectroscopy , inert , materials science , chemistry , hydrolysis , chemical shift , nuclear magnetic resonance , organic chemistry , telecommunications , physics , microbiology and biotechnology , computer science , biology
29 Si nuclear magnetic resonance (NMR) spectroscopy is applied to study the degradation of polysiloxanes (silicones) in vivo. Our results with animal models show that silicone migrates from the implant to the liver ( 29 Si resonance at −20 ppm) and new silicon containing compounds form after the silicones are introduced into the rats. The new 29 Si resonances in the chemical shift range of −40 to −85 ppm are related to hydrolyzed silicone, those at −90 to −115 ppm are indicative of the presence of silica (SiO 2 ), and the peaks observed at −120 to −150 are related to high coordinated silicon complexes. These resonances are not present in the 29 Si spectra of the silicones before implantation. Our findings demonstrate that silicones are not metabolically inert.