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Measurement of T 1 relaxation times of cardiac phosphate metabolites using BIR‐4 adiabatic RF pulses and a variable nutation method
Author(s) -
Sakuma Hajime,
Nelson Sarah J.,
Vigneron Daniel B.,
Hartiala Jaakko,
Higgins Charles B.
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910290517
Subject(s) - nutation , adiabatic process , nuclear magnetic resonance , chemistry , saturation (graph theory) , skeletal muscle , relaxation (psychology) , physics , analytical chemistry (journal) , mathematics , anatomy , medicine , thermodynamics , chromatography , combinatorics , astronomy
T 1 relaxation times of PCr and β‐ATP in human cardiac and skeletal muscle were evaluated using a variable nutation method. This allows T 1 measurements with a constant TR and a significant reduction in acquisition time compared with the partial saturation method. Four 1D CSI datasets were obtained using 30°, 45°, 60°, and 90° BIR‐4 adiabatic RF pulses within 40 min. The T 1 of the phosphate phantom obtained with this method agreed with values obtained with the partial saturation method. The T 1 s of PCr and β‐ATP in heart are 3.98 = 0.18 s and 1.86 ± 0.16 s (mean = SE). Our results demonstrated that T 1 values in heart and skeletal muscle are not significantly different.