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In vivo 1 H chemical shift imaging of silicone implants
Author(s) -
Pfleidere Bettina,
Ackerman Jerome L.,
Garrido Leoncio
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910290512
Subject(s) - in vivo , silicone , nuclear magnetic resonance , chemistry , radiochemistry , materials science , biomedical engineering , nuclear medicine , medicine , physics , biology , composite material , microbiology and biotechnology
In order to study the aging process (i.e., silicone migration, fat infiltration) of silicone (polydimethylsiloxane, PDMS) based biomaterials in living subjects by NMR imaging a hybrid 1 H selective excitation and saturation chemical shift imaging technique (IR/CHESS‐CSSE) has been developed. This sequence allows selective mapping of the distribution of silicone protons in vivo , while suppressing the contributions of fat and water. Our results indicate that a combined inversion recovery and CHESS pulse, followed by a spoiler gradient, must be applied to suppress all contributions of fat protons to the NMR signal. The sensitivity of our experiments allows the detection of a chemically unchanged silicone concentration of 5% in a voxel of 0.9 mm 3 at a signal/noise ratio of 2.