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Diffusion imaging of experimental allergic encephalomyelitis
Author(s) -
Heide A. C.,
Richards T. L.,
Alvord E. C.,
Peterson J.,
Rose L. M.
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910290409
Subject(s) - diffusion mri , encephalomyelitis , magnetic resonance imaging , multiple sclerosis , diffusion imaging , nuclear magnetic resonance , t2 weighted , internal capsule , diffusion , diffusion weighted magnetic resonance imaging , medicine , nuclear medicine , pathology , radiology , white matter , physics , thermodynamics , psychiatry
Diffusion‐weighted magnetic resonance imaging (MRI) was compared with T 2 ‐weighted MRI in longitudinal studies of experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis, in five monkeys ( Macaca fascicularis ). In a region of the brain that had highly directional myelinated fibers (internal capsule) sequential changes were identified on diffusion‐weighted images on and before the day these changes were detected on conventional T 2 ‐weighted images. Changes were also identified on diffusion‐weighted images in brain areas that did not develop T 2 ‐weighted abnormalities. This result suggests that diffusion‐weighted image intensities are sensitive to pathologic conditions of the brain that can not be seen on T 2 ‐weighted images.