Diffusion imaging of experimental allergic encephalomyelitis | Zendy

Heide A. C. | Zendy; Richards T. L. | Zendy; Alvord E. C. | Zendy; Peterson J. | Zendy; Rose L. M. | Zendy

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Diffusion imaging of experimental allergic encephalomyelitis

Author(s) -

Heide A. C.,

Richards T. L.,

Alvord E. C.,

Peterson J.,

Rose L. M.

Publication year - 1993

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910290409

Subject(s) - diffusion mri , encephalomyelitis , magnetic resonance imaging , multiple sclerosis , diffusion imaging , nuclear magnetic resonance , t2 weighted , internal capsule , diffusion , diffusion weighted magnetic resonance imaging , medicine , nuclear medicine , pathology , radiology , white matter , physics , thermodynamics , psychiatry

Diffusion‐weighted magnetic resonance imaging (MRI) was compared with T 2 ‐weighted MRI in longitudinal studies of experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis, in five monkeys ( Macaca fascicularis ). In a region of the brain that had highly directional myelinated fibers (internal capsule) sequential changes were identified on diffusion‐weighted images on and before the day these changes were detected on conventional T 2 ‐weighted images. Changes were also identified on diffusion‐weighted images in brain areas that did not develop T 2 ‐weighted abnormalities. This result suggests that diffusion‐weighted image intensities are sensitive to pathologic conditions of the brain that can not be seen on T 2 ‐weighted images.

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