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Simultaneous temperature and regional blood volume measurements in human muscle using an MRI fast diffusion technique
Author(s) -
Morvan Daniel,
LeroyWillig Anne,
Malgouyres Agnès,
Cuenod Charles A.,
Jehenson Philippe,
Syrota André
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910290313
Subject(s) - diffusion , materials science , nuclear magnetic resonance , temperature gradient , biomedical engineering , effective diffusion coefficient , volume (thermodynamics) , thermal conduction , blood volume , steady state (chemistry) , chemistry , magnetic resonance imaging , thermodynamics , medicine , composite material , physics , radiology , quantum mechanics , cardiology
The thermal dependence of the translational diffusion coefficient and of the regional blood volume was investigated in vivo by using a special MR pulsed gradient technique with reduced sensitivity to bulk tissue motion. Measurements were done at 0.5 T, using a small gradient insert. The diffusion coefficient of muscle water was calibrated against thermocouple‐measured temperature in vitro , both with the muscle fibers parallel and perpendicular to the diffusion gradient. The maximum muscle temperature variation obtained by percutaneous conduction was −8.8 ± 1.6°C under cooling and +3.7 ± 1.6°C under heating, from basal state. Simultaneously the fractional regional blood volume decreased by a factor of 3.5 under cooling and increased by a factor of 2.7 under heating. Due to the interdependence of microcirculation and tissue temperature, this technique may be used to follow heat production or deposition in living tissue (muscle exercise, electromagnetic irradiation, etc.).