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Magnetization transfer characterization of hypertensive cardiomyopathy: Significance of tissue water content
Author(s) -
Scholz Thomas D.,
Ceckler Toni L.,
Balaban Robert S.
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910290311
Subject(s) - magnetization transfer , magnetization , hypertrophic cardiomyopathy , relaxation (psychology) , chemistry , nuclear magnetic resonance , medicine , magnetic resonance imaging , physics , magnetic field , quantum mechanics , radiology
Abstract Magnetization transfer measurements offer the potential for specific noninvasive tissue characterization. The goal of the present study was to determine if changes in magnetization transfer would accompany the myocardial remodeling that occurs with hypertrophic cardiomyopathy. Using 40‐week spontaneously hypertensive rat (SHR) myocardium, T 1 , T 2 , and T 1 in the presence of off‐resonance irradiation ( T 1sat ) were found to be greater compared to Wistar‐Kyoto (WKY) controls. The pseudo‐first order rate constant of magnetization transfer (k for ) was less in 40‐week SHR compared with WKY while the ratio of equilibrium magnetization in the presence and absence of off‐resonance irradiation ( M s / M 0 ) was not different. The extent to which observed interspecies differences in tissue water content affected these parameters was investigated by dehydrating normal and hypertrophic myocardium. Significant correlations found between tissue water content and T 1 , T 2 , T 1sat and k for , but not M s / M 0 , suggested changes in tissue water dominated the observed interspecies differences in relaxation parameters. Thus, ventricular remodeling in hypertrophic cardiomyopathy does not alter magnetization transfer though the accompanying change in tissue water content influences water proton relaxation.