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The sensitivity of magnetic resonance image signals of a rat brain to changes in the cerebral venous blood oxygenation
Author(s) -
Ogawa Seiji,
Lee T. M.,
Barrere Bertrand
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910290208
Subject(s) - oxygenation , magnetic resonance imaging , cerebral blood flow , blood volume , blood flow , venous blood , sensitivity (control systems) , nuclear magnetic resonance , voxel , blood oxygenation , superior sagittal sinus , functional magnetic resonance imaging , cerebral blood volume , signal (programming language) , nuclear medicine , medicine , radiology , physics , programming language , electronic engineering , thrombosis , computer science , engineering
The sensitivity of magnetic resonance image signals of the brain to the change in the cerebral blood oxygenation was measured in gradient echo images of rat brains at a field strength of 7 T. The sensitivity depended on the blood vessel volume relative to the tissue volume within the image voxel, and signal intensities in the cortical area were well correlated with the change in the venous blood de‐oxygenation level at the sagittal sinus. Tissue signals in the image (15 ms echo time) showed a sensitivity of 10‐20% change for the full range of deoxygenation level from 0‐100%. From these observations and image simulations, the extent of the signal response to some neuro‐stimulation which induces an increase in regional cerebral blood flow has been estimated for 4 T field strength.