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Localized proton MR spectroscopy of citrate in vitro and of the human prostate in vivo at 1.5 T
Author(s) -
Schick Fritz,
Bogers Hilmar,
Kurz Siegfried,
Jung WulfIngo,
Pfeffer Markus,
Lutz Otto
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910290109
Subject(s) - in vivo , nuclear magnetic resonance , chemistry , helmholtz coil , echo time , spectroscopy , volume (thermodynamics) , spectral line , signal (programming language) , prostate , magnetic field , physics , magnetic resonance imaging , medicine , radiology , cancer , biology , computer science , microbiology and biotechnology , quantum mechanics , astronomy , programming language
Citrate is a secretory product of the normal prostate, a lack of citrate in prostate tissue is expected to be pathognomonic for adenocarcinoma. In the present study proton AB‐signal characteristics of citrate at low field strength of 1.5 T were investigated by volume selective spectroscopic and theoretical methods. The nonappearance of fast phase modulation of the J‐coupled system at low field strength in vivo is verified by measurements of sodium citrate solution. In vivo localized spectroscopy of small volume elements of (2 cm) 3 with the double spin‐echo method within the prostatic gland provides citrate signal reception even using a Helmholtz coil with 170‐mm diameter. Volume selective proton spectra with different echo times are presented which are comparable to spectra acquired by former authors with endorectal coils.