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The origin of biexponential T2 relaxation in muscle water
Author(s) -
Cole William C.,
Leblanc Adrian D.,
Jhingran Satish G.
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910290106
Subject(s) - intracellular , chemistry , relaxation (psychology) , extracellular , macromolecule , muscle tissue , biophysics , proton , nuclear magnetic resonance , t2 relaxation , anatomy , biochemistry , magnetic resonance imaging , biology , physics , medicine , radiology , quantum mechanics , neuroscience
Two theories have been proposed to explain the multiexponential transverse relaxation of muscle water protons: “anatomical” and “chemical” compartmentation. In an attempt to obtain evidence to support one or the other of these two theories, interstitial and intracellular macromolecular preparations were studied and compared with rat muscle tissue by proton NMR transverse relaxation (T2) measurements. All macromolecule preparations displayed monoexponential T2 decay. Membrane alteration with DMSO/glycerin did not eliminate the biexponential T2 decay of muscle tissue. Maceration converted biexponential T2 decay of muscle tissue to single exponential decay. It is concluded that the observed two component exponential T2 decay of muscle represents anatomical compartmentation of tissue water, probably intracellular versus extracellular.