1 /T 1p  and Low‐Field 1 / T 1  of Tissue Water Protons Arise from Magnetization Transfer to Macromolecular Solid‐State Broadened Lines | Zendy

Brown Rodney D. | Zendy; Koenig Seymour H. | Zendy

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1 /T 1p and Low‐Field 1 / T 1 of Tissue Water Protons Arise from Magnetization Transfer to Macromolecular Solid‐State Broadened Lines

Author(s) -

Brown Rodney D.,

Koenig Seymour H.

Publication year - 1992

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910280115

Subject(s) - magnetization , proton , magnetization transfer , solvent , field (mathematics) , mixing (physics) , spin (aerodynamics) , nuclear magnetic resonance , chemistry , magnetic field , chemical physics , materials science , condensed matter physics , physics , thermodynamics , nuclear physics , medicine , mathematics , organic chemistry , quantum mechanics , magnetic resonance imaging , pure mathematics , radiology

We argue that, for solutions of immobilized protein and for tissue, the dependence of 1 / T 1 of solvent protons on B 0 at low fields and 1 / T 1p on B 1 for all B 0 are both manifestations of the same underlying phenomena: magnetization transfer between mobile water protons and solid‐state broadened protein proton levels. Broadening causes rapid mixing of spin orientation within the transverse plane, at all B 0 , unless B 1 is greater than the protein internal field; this affects 1 / T 1p of solvent protons by magnetization transfer. Similarly, decreasing B 0 below the internal field mixes all orientations of magnetization, which affects the solvent proton low‐field 1 / T 1 and high‐field 1 / T 2 .© 1992 Academic Press,Inc.

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