Premium
1 /T 1p and Low‐Field 1 / T 1 of Tissue Water Protons Arise from Magnetization Transfer to Macromolecular Solid‐State Broadened Lines
Author(s) -
Brown Rodney D.,
Koenig Seymour H.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910280115
Subject(s) - magnetization , proton , magnetization transfer , solvent , field (mathematics) , mixing (physics) , spin (aerodynamics) , nuclear magnetic resonance , chemistry , magnetic field , chemical physics , materials science , condensed matter physics , physics , thermodynamics , nuclear physics , medicine , mathematics , organic chemistry , quantum mechanics , magnetic resonance imaging , pure mathematics , radiology
We argue that, for solutions of immobilized protein and for tissue, the dependence of 1 / T 1 of solvent protons on B 0 at low fields and 1 / T 1p on B 1 for all B 0 are both manifestations of the same underlying phenomena: magnetization transfer between mobile water protons and solid‐state broadened protein proton levels. Broadening causes rapid mixing of spin orientation within the transverse plane, at all B 0 , unless B 1 is greater than the protein internal field; this affects 1 / T 1p of solvent protons by magnetization transfer. Similarly, decreasing B 0 below the internal field mixes all orientations of magnetization, which affects the solvent proton low‐field 1 / T 1 and high‐field 1 / T 2 .© 1992 Academic Press,Inc.