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13 C and 1 H NMR Study of the Metabolic Degradation of 4‐Pentenoate in Different Dog Nephron Segments
Author(s) -
Boulanger Yvan,
Wong Hong,
Fleser Angelica,
Commodari Fernando,
Vinay Patrick
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910280114
Subject(s) - chemistry , degradation (telecommunications) , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , stereochemistry , physics , computer science , telecommunications
The metabolism of 4‐pentenoate in isolated kidney tubules has been investigated by 1 H and 13 C NMR. The 4‐pentenoate metabolite, 3‐keto‐4‐pentenoyl‐CoA, accumulated in proximal tubules only and its formation could be competitively inhibited by octanoate. 4‐Pentenoate was metabolized in thick ascending limbs but not in papillary collecting ducts.© 1992 Academic Press,Inc.