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Atraumatic quantitation of cerebral perfusion in cats by 19 f magnetic resonance imaging
Author(s) -
Branch Craig A.,
Ewing James R.,
Helpern J. A.,
Ordidge R. J.,
Butt Shazad,
Welch K. M. A.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910280105
Subject(s) - normocapnia , hypercapnia , cerebral blood flow , magnetic resonance imaging , nuclear magnetic resonance , perfusion , cats , cerebral perfusion pressure , nuclear medicine , voxel , chemistry , medicine , physics , radiology , respiratory system
We have noninvasively produced low‐resolution, quantitative nuclear magnetic resonance images of cerebral blood flow in 2‐ml voxels in eight cats. Typical signal‐to‐noise of 4 to 1 was obtained in cerebral voxels in 16.5‐s epochs. Mean flow during normocapnia (p a CO 2 = 39 ± 4 mm Hg) and hypercapnia (p a CO 2 = 62 ± 4 mm Hg) was 53 ± 20 ml/100 gmin and 140 ± 36 ml/100 g‐min, respectively. Fast flows in normocapnia were 94 ± 13 and 182 ± 39 ml/100 g‐min in hypercapnia. These results suggest that an atraumatic quantitative imaging assessment of cerebral perfusion may be possible in humans using these techniques.© 1992 Academic Press,Inc.