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Mr imaging of cerebral perfusion by phase‐angle reconstruction of bolus paramagnetic‐induced frequency shifts
Author(s) -
Conturo Thomas E.,
Barker Peter B.,
Mathews Vincent P.,
Monsein Lee H.,
Bryan R. Nick
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910270219
Subject(s) - nuclear magnetic resonance , paramagnetism , white matter , magnetic resonance imaging , phase (matter) , perfusion , nuclear medicine , perfusion scanning , bolus (digestion) , signal (programming language) , materials science , chemistry , physics , medicine , radiology , anatomy , organic chemistry , computer science , programming language , quantum mechanics
Phase‐angle images are acquired dynamically during bouls paramagnetic contrast injection and demonstrate a phase‐enhancement effect in perfused cerebral tissues. Signal‐to‐noise is comparable to that of susceptibility‐based signal loss (ΔR) images. Assuming that phase shift is proportional to the tissue paramagnetic agent concentration, as supported by experimental data, the integrated area of the phase time response curves estimated the relative gray to white matter blood volume as 1.8:1 and was sensitive to acute ischemia. The relation between tissue phase shift and concentration is considered.