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Changes in probe sensitivity during nmr spectroscopic studies of the perfused rat heart: a warning
Author(s) -
Nédélec JeanFrançois,
Saunders John K.,
Morris Paul,
Clarke Kieran
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910270214
Subject(s) - mannitol , perfusion , chemistry , sensitivity (control systems) , nuclear magnetic resonance , cardiology , medicine , biochemistry , physics , electronic engineering , engineering
During NMR experiments on isolated, perfused rat heart, we observed a 57% change in probe sensitivity when the perfusion buffer surrounding the heart was replaced by either a low‐ionic‐strength mannitol solution or air and the heart was made ischemic. Such changes in sensitivity, should they go unrecognized, would result in substantial quantification errors.