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Detection and assignment of the glucose signal in 1 h nmr difference spectra of the human brain
Author(s) -
Gruetter Rolf,
Rothman Douglas L.,
Novotny Edward J.,
Shulman Gerald I.,
Prichard James W.,
Shulman Robert G.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910270118
Subject(s) - nuclear magnetic resonance , spectral line , chemistry , nmr spectra database , physics , astronomy
The difference between 1 H NMR spectra obtained during eu‐ and hyperglycemia exhibited well‐resolved glucose peaks between 3 and 4 ppm as demonstrated by comparison with solution spectra. Estimated increases were consistent with recent 13 C NMR quantitations of intracerebral glucose. Difference spectra were measured in 36‐ml volumes from the human brain every 3 min.