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T 1 values of phosphomonoester and phosphocreatine of brain show no significant change during development
Author(s) -
Hida Kazutoshi,
Kwee Ingrid L.,
Nakada Tsutomu
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910270117
Subject(s) - phosphocreatine , chemistry , medicine , endocrinology , spin–lattice relaxation , nuclear magnetic resonance , biology , energy metabolism , physics , nuclear quadrupole resonance
Changes in apparent 31 P spin‐lattice relaxation times ( T 1 ) associated with brain development were investigated in rat pups. While analysis of variance showed strong age dependency in [PME]/[ATP] and [PCr]/[ATP], the T 1 values of PME, PCr, and ATP did not show any age dependency. The studies indicate that in contrast to the data which indicated aging‐related changes in the T 1 values of PME, the observed changes in PME during neonatal development are likely to be quantitative in nature.