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Measurement of blood‐brain barrier permeability in a tumor model using magnetic resonance imaging with gadolinium‐dtpa
Author(s) -
Kenney James,
Schmiedl Udo,
Maravilla Kenneth,
Starr Frank,
Graham Michael,
Spence Alexander,
Nelson James
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910270108
Subject(s) - gadolinium , magnetic resonance imaging , nuclear magnetic resonance , chemistry , permeability (electromagnetism) , glioma , nuclear medicine , gadolinium dtpa , medicine , radiology , physics , biochemistry , organic chemistry , cancer research , membrane
Sequential MR imaging with gadolinium‐diethylenetriaminepentaacetic acid (Gd‐DTPA) and sequential measurements of plasma Gd‐DTPA concentration by inductively coupled plasma atomic emission spectroscopy (ICP‐AES) were used to estimate the blood‐to‐tissue transport coefficient (K i ) in the 36B‐10 rat glioma model. For these measurements, tissue Gd‐DTPA concentration was estimated from tumor enhancement by correlation with calibration measurements obtained by ICP‐AES analysis of tumor tissue. The 14 animals for which K i , was calculated can be grouped into those imaged at 11 days following tumor implantation, at 13‐18 days, and at 20 days. The mean (+SEM) K i values for these groups were 1.1 + 0.24, 9.2 + 0.8, and 13.4 + 1.7 ml/kg‐min, respectively. These results correspond well with published data obtained by quantitative autoradiography. It is concluded that frequent sequential imaging and a graphical approach to K i , calculation are promising methods for determining the blood‐to‐tissue transport coefficient noninvasively by contrastenhanced MRI.