Premium
Direct measurement of spin‐lattice relaxation times of Phosphorus Metabolites in Human Myocardium
Author(s) -
Neubauer S.,
Krahe T.,
Schindler R.,
Hillenbrand H.,
Entzeroth C.,
Horn M.,
Bauer W. R.,
Stephan T.,
Lackner K.,
Haase A.,
Ertl G.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910260209
Subject(s) - creatine , phosphocreatine , chemistry , nuclear magnetic resonance , creatine kinase , inorganic phosphate , analytical chemistry (journal) , phosphate , spectral line , medicine , energy metabolism , chromatography , biochemistry , physics , astronomy
T1 values of phosphorus metabolites visible in human cardiac 31 P‐MR spectra were determined in 12 volunteers at 1.5 T. Consecutive spectra were acquired with varying pulse repetition time (TR) from 1.6 to 24 s; volume selection was achieved with ISIS. T 1's of creatine phosphate (CP), [γ‐P], [α‐P], and [β‐P] ATP, 2‐3 diphosphoglycerate, and phosphodiesters were 6.1 ± 0.5, 5.4 ± 4 0.5, 5.5 ± 0.5, 5.8 ± 1.0, 7.6 ± 1.0, and 5.0 ± 1.0 s, respectively. CP/ATP ratios showed little change with varying TR; linear regression of CP/ATP vs TR was of borderline significance ( r = 0.28, P = 0.06). T1'S for CP and ATP were also determined in standard solution (20 m M CP, 10 m M ATP) yielding TI cp of 8.7 ± 0.2 and T1 [γ‐P]‐atp of 9.9 ± 0.7 s. Thus, T1'S for CP and ATP were similar at 1.5 T in both human heart and standard solution. In human cardiac 31 P‐MR spectra, CP/ATP ratios may need little correction for partial saturation.