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Effects of the interaction between ferric iron and L‐dopa melanin on T1 and T2 relaxation times determined by magnetic resonance imaging
Author(s) -
Tosk Jeffrey M.,
Holshouser Barbara A.,
Aloia Roland C.,
Hinshaw David B.,
Hasso Anton N.,
Macmurray James P.,
Will A. Douglas,
Bozzetti Louis P.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910260105
Subject(s) - neuromelanin , melanin , nuclear magnetic resonance , relaxation (psychology) , magnetic resonance imaging , chemistry , magnetic relaxation , paramagnetism , ferric , spin–lattice relaxation , dopamine , physics , biology , biochemistry , substantia nigra , endocrinology , magnetic field , medicine , magnetization , neuroscience , condensed matter physics , radiology , quantum mechanics , organic chemistry , nuclear quadrupole resonance , dopaminergic
T1 and T2 relaxation times of agar phantoms containing L‐dopa melanin and Fe 3+ were measured under MRI conditions. Fe 3+ shortened T1 and T2 relaxation times. Melanin influenced relaxation times only in the presence of Fe 3+ ; thus, contrast in MR images of the basal ganglia may depend upon levels of both paramagnetic iron and neuromelanin.