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In vivo 7 Li NMR imaging and localized spectroscopy of rat brain
Author(s) -
Ramaprasad S.,
Newton J. E. O.,
Cardwell D.,
Fowler A. H.,
Komoroski R. A.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910250209
Subject(s) - nuclear magnetic resonance , spectroscopy , nuclear magnetic resonance spectroscopy , relaxation (psychology) , chemistry , spin–lattice relaxation , isotopes of lithium , in vivo , lithium (medication) , in vivo magnetic resonance spectroscopy , radiofrequency coil , magnetic resonance imaging , physics , ion , medicine , organic chemistry , radiology , quantum mechanics , ion exchange , nuclear quadrupole resonance , endocrinology , microbiology and biotechnology , biology
Abstract Lithium‐7 in vivo NMR spectroscopy and imaging techniques have been developed at 4.7 T for rat head. The pharmacokinetics of lithium (Li) uptake in rat head has been measured using STEAM localized spectroscopy for the whole brain, which showed relatively rapid uptake of Li and a steady level of Li from about 5 to 20 h. Localized spectroscopy on brain sections revealed no differences in Li concentration among the front, middle, and rear of the brain. The spin‐lattice relaxation time showed a single exponential decay for the head. The spin‐spin relaxation time for head showed a biexponential behavior. Using a 1 H‐ 7 Li double coil assembly, 7 Li images were generated for rat head, as was the corresponding 1 H image for anatomic localization. The 7 Li image (7‐mm slice thickness, 4‐mm in‐plane resolution) recorded after the last dose in a multiple ip dose protocol shows the Li distribution in the head and neck. Based on 7 Li images, the Li level in muscle was about twice that in the brain. Variations of 7 Li intensity level across the brain were typically small. © 1992 Academic Press, Inc.