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1 H spectroscopic imaging of rat brain at 7 tesla
Author(s) -
Fernandez E. J.,
Maudsley A. A.,
Higuchi T.,
Weiner M. W.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910250111
Subject(s) - phosphocreatine , metabolite , creatine , nuclear magnetic resonance , choline , chemistry , spin echo , magnetic resonance imaging , magnetic resonance spectroscopic imaging , physics , medicine , biochemistry , radiology , energy metabolism
1 H magnetic resonance spectroscopic imaging has been used to obtain metabolite maps of the rat brain. The spin‐echo‐based technique has been evaluated with respect to water and lipid suppression and sensitivity. Metabolite maps were constructed for choline. creatine + phosphocreatine, amino acids, Nacetyl aspartate, and lactate. A spatial resolution of 3 × 3 mm (in plane) with 7‐mm‐thick slices was achieved routinely in 60‐min (16 × 16 phase encoding) acquisitions. For higher intensity resonances, metabolite maps could be constructed in as little as 10 min. Results from phantoms and from rats under normal and focal ischemia conditions are presented.