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Localized 1 H NMR spectra of glutamate in the human brain
Author(s) -
Rothman D. L.,
Hanstock C. C.,
Petroff O. A. C.,
Novotny E. J.,
Prichard J. W.,
Shulman R. G.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910250110
Subject(s) - glutamine , glutamate receptor , nuclear magnetic resonance , creatine , human brain , chemistry , resonance (particle physics) , spectral line , nuclear magnetic resonance spectroscopy , biochemistry , amino acid , biology , physics , neuroscience , receptor , particle physics , astronomy
Localized 1 H NMR spectra at TE = 12 ms were obtained from cerebralcortex of human subjects using ISIS with surface suppression. The 2.29‐ppm resonance was assigned to C4 glutamate with contributions from C4 glutamine and GABA using in vivo spectral editing and comparison of chemical shift with pure compounds. The measured intensity ratio between the 2.29 resonance and the creatine resonance at 3.03 ppm was in good agreement with the ratio predicted from previously reported measurements of glutamate. glutamine, and GABA concentrations in biopsied human brain tissue.