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Proton overhauser enhancements in human cardiac phosphorus NMR spectroscopy at 1.5 T
Author(s) -
Bottomley Paul A.,
Hardy Christopher J.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910240220
Subject(s) - phosphocreatine , nuclear overhauser effect , adenosine triphosphate , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , chemistry , proton , medicine , biochemistry , physics , energy metabolism , quantum mechanics
Narrowband irradiation of water protons with a surface coil yields significant nuclear Overhauser enhancement (nOe) of phosphocreatine (PCr) and some adenosine triphosphate (ATP) moieties in localized and unlocalized phosphorus ( 31 P) NMR spectra from chest and heart muscle. In seven normal subjects at 1.5 T the nOe values were 0.6 ± 0.3, 0.6 ± 0.3, 0 ± 0.3, and 0.3 ± 0.2 for myocardial PCr, γ‐ATP, α‐ATP, and β‐ATP, respectively, not significantly different from those in chest muscle. Distortion of the measured PCr/ATP ratios due to differences in the nOe may require accurate correction to realize the full benefit of the effect in studies involving quantitative intergroup comparisons. © 1992 Academic Press, Inc.