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T 1ρ dispersion imaging and localized T 1ρ dispersion relaxometry: Application in vivo to mouse adenocarcinoma
Author(s) -
Rommel E.,
Kimmich R.,
Körperich H.,
Kunze C.,
Gersonde K.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910240115
Subject(s) - relaxometry , nuclear magnetic resonance , dispersion (optics) , in vivo , magnetic resonance imaging , relaxation (psychology) , spin–lattice relaxation , chemistry , materials science , spin echo , physics , optics , biology , medicine , radiology , microbiology and biotechnology , neuroscience , nuclear quadrupole resonance
The dispersion (frequency dependence) of the spin‐lattice relaxation time in the rotating frame, T 1ρ , is considered for tissue characterization. Methods for the volume‐selective determination of the proper T 1ρ , dispersion and for imaging of parameters characterizing this frequency dependence are described. On‐ and off‐resonance versions of the techniques are demonstrated. In vitro studies of excised rat tissues and in vivo applications to mice with implanted adenocarcinoma are reported. T 1ρ , dispersion images show clear contrasts of the malignant tissue, whereas muscle tissue is completely suppressed. No contrast agent is required. The measuring time is only twice as long as that for conventional magnetic resonance images. The results suggest that the T 1ρ , dispersion is less susceptible to the biological variability than the absolute values of the relaxation times. © 1992 Academic Press, Inc.