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Proton nuclear magnetic resonance studies on water structure in peritumoral edematous brain tissue
Author(s) -
Iwama T.,
Yamada H.,
Era S.,
Sogami M.,
Andoh T.,
Sakai N.,
Kato K.,
Kuwata K.,
Wataris H.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910240106
Subject(s) - nuclear magnetic resonance , brain tissue , proton , chemistry , relaxation (psychology) , magnetic resonance imaging , free water , spin–lattice relaxation , electrolyte , pathology , medicine , anatomy , radiology , physics , quantum mechanics , environmental engineering , engineering , electrode , nuclear quadrupole resonance
Spin–lattice relaxation times ( T 1 ) of water protons and cross‐relaxation times ( T IS ) between irradiated protein and water protons were measured to study the water structure in peritumoral edematous brain tissue of rats. Despite small changes in T 1 , water, and electrolyte contents, T IS values of water protons were significantly reduced in peritumoral edematous brain tissue when compared to those of the controls. Results indicate that the water structure in brain tissues may become altered at an early stage of edemic formation without causing any significant changes in cellular hydration. T IS , might serve as a sensitive parameter for studying the water structure in a variety of tissues, such as in edematous brain tissue. © 1992 Academic Press, Inc.