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Perfusion imaging
Author(s) -
Detre John A.,
Leigh John S.,
Williams Donald S.,
Koretsky Alan P.
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910230106
Subject(s) - perfusion , nuclear magnetic resonance , cerebral blood flow , spins , saturation (graph theory) , blood flow , perfusion scanning , chemistry , human brain , materials science , nuclear medicine , biomedical engineering , medicine , physics , biology , mathematics , radiology , neuroscience , combinatorics
Measurement of tissue perfusion is important for the functional assessment of organs in vivo. Here we report the use of 1 H NMR imaging to generate perfusion maps in the rat brain at 4.7 T. Blood water flowing to the brain is saturated in the neck region with a sliceselective saturation imaging sequence, creating an endogenous tracer in the form of proximally saturated spins. Because proton T 1 times are relatively long, particularly at high field strengths, saturated spins exchange with bulk water in the brain and a steady state is created where the regional concentration of saturated spins is determined by the regional blood flow and regional T 1 . Distal saturation applied equidistantly outside the brain serves as a control for effects of the saturation pulses. Average cerebral blood flow in normocapnic rat brain under halothane anesthesia was determined to be 105 ± 16 cc. 100 g −1 . min −1 (mean ± SEM, n = 3), in good agreement with values reported in the literature, and was sensitive to increases in arterial p CO 2 . This technique allows regional perfusion maps to be measured noninvasively, with the resolution of 1 H MRI, and should be readily applicable to human studies. © 1992 Academic Press, Inc.