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In vivo 1 H and 31 P NMR spectroscopy of the developing rat brain
Author(s) -
Hida Kazutoshi,
Kwee Ingrid L.,
Nakada Tsutomu
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910230105
Subject(s) - taurine , phosphocreatine , choline , in vivo , nuclear magnetic resonance spectroscopy , fetus , endocrinology , medicine , nuclear magnetic resonance , biology , chemistry , pregnancy , amino acid , biochemistry , physics , energy metabolism , genetics , microbiology and biotechnology
The biochemical changes associated with brain maturation during the first 28 days postnatal were investigated utilizing proton and phosphorus‐31 nuclear magnetic resonance spectroscopy in rat pups in vivo. Phosphocreatine was found to increase linearly during this period of development. Phosphomonoester was high at birth, peaked around the 10th day postnatal, and declined thereafter. N ‐Acetyl‐aspartate was low at birth, increased in an approximately linear fashion, and reached adult levels by about Day 28 postnatal. Choline was high at birth and declined thereafter. Taurine, a sulfur amino acid abundant in fetal brain, was also present in high levels on the first day postnatal. © 1992 Academic Press, Inc.