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Hypercarbia‐induced changes in cerebral blood volume in the cat: A 1 H MRI and intravascular contrast agent study
Author(s) -
Moseley Michael E.,
Chew Wil M.,
White David L.,
Kucharczyk John,
Litt Lawrence,
Derugin Nikita,
Dupon Jean,
Brasch Robert C.,
Norman David
Publication year - 1992
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910230104
Subject(s) - cerebral blood flow , blood volume , hypercarbia , magnetic resonance imaging , nuclear magnetic resonance , contrast (vision) , chemistry , white matter , cerebral blood volume , nuclear medicine , medicine , radiology , cardiology , physics , optics , hypoxemia
Abstract Cerebral blood volume changes with arterial carbon dioxide were monitored by proton T1‐weighted MR images following administration of the intravascular contrast agent Gd‐DTPA labeled with human serum albumin. Without MR contrast, no significant image intensity changes were observed with P a CO 2 . Following contrast, regional brain image intensities increased significantly over control (0% inspired CO 2 ) in cortical gray, white, and basal ganglia regions with increasing P a CO 2 and returned to control intensities upon return to 0% inspired CO 2 . Imaging of through‐plane and in‐plane phantoms was performed to assess flow effects. Signal losses of 2 and 6% (relative to no flow) were observed for bulk velocities of 5 mm/s at TE values of 15 ms. An intravascular contrast agent may be useful for MRI monitoring of local cerebral blood volume changes during cerebral perturbations. © 1992 Academic Press, Inc.