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A new method for the evaluation of the liver injury by 19 F MRS of 5‐fluorouracil
Author(s) -
Harada Masafumi,
Koga Keiko,
Miura Iwao,
Nishitani Hiromu
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910220257
Subject(s) - uracil , fluorouracil , liver injury , metabolism , chemistry , medicine , biochemistry , chemotherapy , dna
An investigation was made of 5‐fluorouracil metabolism in rat liver by 19 F MRS. Fluoronucleotide synthesis increased markedly with liver injury and accelerated with uracil treatment, indicating that 19 F MRS may serve as a new method for evaluating liver viability. © 1991 Academic Press, Inc.