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Measurement of water movement in the rabbit eye in vivo using H 2 17 O
Author(s) -
Kwong Kenneth K.,
Xiong Jing,
Kuan WeiPeng,
Cheng HongMing
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910220252
Subject(s) - in vivo , aqueous solution , proton , nuclear magnetic resonance , chemistry , proton magnetic resonance , aqueous humor , analytical chemistry (journal) , materials science , chromatography , physics , ophthalmology , medicine , nuclear physics , microbiology and biotechnology , biology
Topically applied (eyedrop) H 2 17 O (10% enrichment) was used in magnetic resonance studies to quantify intraocular water dispersion in vivo . The rate of H 2 17 O removed from the aqueous chamber is in the order of 0.1 ml/min/ml of tissue. Similar results are obtained with either proton imaging or 17 O spectroscopy. Parallel experiments of direct injection of H 2 17 O into the aqueous chamber supported the topical data. Proton MR imaging of H 2 17 O dissipation from the aqueous chamber with clinical imagers, coupled with eyedrop application. suggerts clinical possibilites. © 1991 Academic Press, Inc.