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31 P spectroscopy of the human prostate gland in vivo using a transrectal probe
Author(s) -
Kurhanewicz John,
Thomas Albert,
Jajodia Prahalad,
Weiner Michael W.,
James Thomas L.,
Vigneron Daniel B.,
Narayan Perinchery
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910220248
Subject(s) - phosphocreatine , prostate , in vivo , in vivo magnetic resonance spectroscopy , prostatic disease , chemistry , nuclear magnetic resonance , spectroscopy , nuclear magnetic resonance spectroscopy , magnetic resonance imaging , pathology , medicine , nuclear medicine , endocrinology , cancer , biology , radiology , energy metabolism , physics , microbiology and biotechnology , quantum mechanics
Using a transrectal probe, good quality 31 P magnetic resonance spectroscopy of the human prostate was performed safely, consistently, and in a reasonable amount of time (average of 60 min). Initial results indicate that transrectal 31 P MRS has the ability to characterize the phosphorylated metabolites of normal, hyperplastic, and malignant prostates. This study demonstrated that malignant prostates are characterized by significantly decreased levels of phosphocreatine (PCr) and increased levels of phosphomonesters (PME) as compared to healthy prostates. © 1991 Academic Press, Inc.