The stability of proton  T  2  effects of oxygen‐17 water in experimental cerebral ischemia | Zendy

Hopkins A. L. | Zendy; Lust W. D. | Zendy; Haacke E. M. | Zendy; Wielopolski P. | Zendy; Barr R. G. | Zendy; Bratton C. B. | Zendy

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The stability of proton T 2 effects of oxygen‐17 water in experimental cerebral ischemia

Author(s) -

Hopkins A. L.,

Lust W. D.,

Haacke E. M.,

Wielopolski P.,

Barr R. G.,

Bratton C. B.

Publication year - 1991

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910220118

Subject(s) - gerbil , ischemia , ligation , oxygen , brain tissue , anesthesia , medicine , carotid arteries , cardiology , magnetic resonance imaging , nuclear magnetic resonance , chemistry , radiology , physics , organic chemistry

The gerbil model of unilateral cerebral ischemia has been used to test the temporal and spatial stability of the MRI T 2 effects of oxygen‐17 water. Following unilateral carotid ligation, symptomatic animals were given a single large intraperitoneal injection of H 2 17 O and the distribution and stability of the brain T 2 effects were followed with a spin‐echo sequence. In contrast to the ischemic areas, the perfused tissue shows a marked and prolonged loss in intensity with little evidence of diffusion of the T 2 effect of 17 O into the ischemic tissue. © 1991 Academic Press, Inc.

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