Premium
The stability of proton T 2 effects of oxygen‐17 water in experimental cerebral ischemia
Author(s) -
Hopkins A. L.,
Lust W. D.,
Haacke E. M.,
Wielopolski P.,
Barr R. G.,
Bratton C. B.
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910220118
Subject(s) - gerbil , ischemia , ligation , oxygen , brain tissue , anesthesia , medicine , carotid arteries , cardiology , magnetic resonance imaging , nuclear magnetic resonance , chemistry , radiology , physics , organic chemistry
The gerbil model of unilateral cerebral ischemia has been used to test the temporal and spatial stability of the MRI T 2 effects of oxygen‐17 water. Following unilateral carotid ligation, symptomatic animals were given a single large intraperitoneal injection of H 2 17 O and the distribution and stability of the brain T 2 effects were followed with a spin‐echo sequence. In contrast to the ischemic areas, the perfused tissue shows a marked and prolonged loss in intensity with little evidence of diffusion of the T 2 effect of 17 O into the ischemic tissue. © 1991 Academic Press, Inc.