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In Vivo measurement of cerebral oxygen consumption and blood flow using 17 O magnetic resonance imaging
Author(s) -
Pekar J.,
Ligeti L.,
Ruttner Z.,
Lyon R. C.,
Sinnwell T. M.,
van Gerderen P.,
Fiat D.,
Moonen C. T. W.,
McLaughlin A. C.
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910210217
Subject(s) - magnetic resonance imaging , in vivo , nuclear magnetic resonance , cerebral blood flow , oxygen , blood flow , chemistry , medicine , cardiology , radiology , physics , biology , microbiology and biotechnology , organic chemistry
We used 17 O NMR imaging techniques to measure the H 2 17 O concentration in a 0.8‐ml voxel in the cat brain following injection of an arterial bolus of enriched H 2 17 O and during inhalation of enriched 17 O 2 . We also measured the H 2 17 O concentration in arterial blood during 17 O 2 inhalation. The data from the first measurement were used to calculate the blood flow in the voxel. The data from all three measurements were combined to calculate the oxygen consumption in the voxel. The values of cerebral blood flow and oxygen consumption calculated with 17 O NMR techniques agree reasonably well with values calculated for a similar region of the cat brain using autoradiographic techniques. © 1991 Academic Press, Inc.