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Proton spectroscopic imaging: A tool for studying intracerebral tumor models in rat
Author(s) -
Bourgeois D.,
Remy C.,
Lefur Y.,
Devoulon P.,
Benabid A. L.,
Decorps M.
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910210104
Subject(s) - nuclear magnetic resonance , in vivo , choline , pulse sequence , pulse (music) , creatine , in situ , chemistry , proton , echo time , excitation , resolution (logic) , nuclear medicine , magnetic resonance imaging , materials science , optics , physics , medicine , biology , radiology , biochemistry , microbiology and biotechnology , organic chemistry , quantum mechanics , artificial intelligence , detector , computer science
Water‐suppressed 2D 1 H spectroscopic imaging was used with surface coils to study in vivo the cerebral metabolism changes in rat brain induced by a glial tumor growing in situ . To achieve slice selection without a chemical‐shift artifact, we exploited the depth pulse properties of a spin‐echo sequence. In order to give a spectral response which is independent of the position, the water suppression was achieved by using a spin‐locking excitation and a binomial refocusing pulse. Spectroscopic images were obtained with an in‐plane resolution of 1.1 × 1.1 mm and a slice thickness of roughly 3 mm. The growing of the tumor induced dramatic modifications in the proton spectra, including a nearly complete loss of N ‐acetyl aspartate, an increase of the 1.3‐ppm peak, an increase in choline, and a decrease in creatine. The results demonstrate the potential of spectroscopic imaging in the study of intracranial tumor models in rats. © 1991 Academic Press, Inc.