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Oblique NMR imaging of the uterus in macaques: Uterine resdonse to estrogen stimulation
Author(s) -
Waterton John C.,
Miller Diane,
Dukes Michael,
Morrell John S. W.
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910200206
Subject(s) - uterus , estradiol benzoate , endometrium , estrogen , ovariectomized rat , stimulation , cervix , medicine , basal (medicine) , anatomy , chemistry , endocrinology , cancer , insulin
We report methods for quantitative NMR imaging of the primate uterus and the application of these methods of measuring the response of the monkey ( Macaca nemestrina ) uterus (endometrial volume. myometrial volume, T 2 values, myometrial junction zone) to estrogen stimulation. High‐gield (2.35 T), fat‐suppressed, T 2 ‐weighted (TE50) oblique methods were used, Slice thickeness, location, and angle were varied on each examination to obtain six contiguous slices between the cervix and fundus, regardles of size or orientation of the uterus. Basal endometrial and myometrial volumes were 0.05± 0.01 cm 3 and 1.31 ± 0.23 cm 3 in chronically ovariectomized animals. These increased by 15.7 ± 3.6‐fold and 3.1 ± 0.4 fold, respectively, during 7 days of estrogen stimulation (estradiol benzoate, 5 ųg/kg sc daily) while myometrial T 2 increased from 52 ± 1 to 67 ± 4 ms. These changes reversed following menstrual bleeding. © 1991 Academic Press, Inc.