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Multinuclear MR investigation of the metabolic response of the murine RIF‐1 tumor to 5‐fluorouracil chemotherapy
Author(s) -
Sijens Paul E.,
Baldwin Nicholas J.,
Ng Thian C.
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910190228
Subject(s) - chemotherapy , fluorouracil , tumor cells , chemistry , nuclear medicine , medicine , cancer research
The metabolic response of the RIF‐1 tumor to 5‐fluorouracil (a single dose of 260 mg 5FU/kg, ip) was monitored in 10 mice using 19 F and 31 P MR spectroscopy. 19 F MRS revealed a continuous drop in tumor 5FU level and an increase in the fluoronucleotide (Fnuc) signal to a plateau value of 50% of the initial 5FU level, during the first 2 h after chemotherapy. Although the 31 P MR spectra of the tumors showed no significant initial changes, the total level of MR visible tumor phosphate decreased and tumor pH increased during the subsequent days. The changes in phosphate metabolism and tumor pH did not correlate with the detected fluorine levels or tumor response. However, the pretreatment Pi level, the plateau Fnuc level, and the 5FU induced decrease in tumor volume showed significant correlation. The indicates that both 19 F and 31 P MR spectroscopy have potential for predicting reponse to 5FU chemotherapy. © 1991 Academic Press, Inc.