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The visibility of the 1 H NMR signal of ethanol in the dog brain
Author(s) -
Moxon Leith N.,
Rose Stephen E.,
Haseler Luke J.,
Galloway Graham J.,
Brereton Ian M.,
Bore Peter,
Doddrell David M.
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910190225
Subject(s) - visibility , chemistry , ethanol , nuclear magnetic resonance , signal (programming language) , physics , computer science , biochemistry , optics , programming language
In Vivo , high‐resolution, volume‐selected 1 H NMR spectroscopy was used to monitor the concentration of ethanol in the dog brain following intravenous injection of ethanol. Equilibration of ethanol in the body water should result in approximately equivalent concentrations of ethanol in the blood and brain. However, the mean equilibrium brain ethanol concentration determined using N‐acetylaspartate as an internal standard was only 23 ± 5% of the blood ethanol concentration. The disparity between blood and brain ethanol concentrations was attributed to underestimation of the ethanol concentration due to overlapping resonances with NAA and to T 2 attenuation or possible nondetection of the 1 H signal from ethanol bound at the surface of cell membranes and partitioned into the hydrophobic core of membrane lipids. © 1991 Academic Press, Inc.