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Noninvasive temperature imaging using diffusion MRI
Author(s) -
Delannoy J.,
Chen ChingNien,
Turner R.,
Levin R. L.,
Le Bihan D.
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910190224
Subject(s) - imaging phantom , thermocouple , hyperthermia , materials science , nuclear magnetic resonance , biomedical engineering , electromagnetic coil , diffusion , volume (thermodynamics) , temperature measurement , nuclear medicine , medicine , physics , composite material , thermodynamics , quantum mechanics
Efficacy and safety considerations for cancer therapy with hyperthermia require accurate temperature measurements throughout the heated volume. We report the use of molecular diffusion, whose temperature dependence is well known. A dedicated hyperthermia applicator was built, combining a MRI gradient coil and a rf coil. Diffusion and derived temperature images were obtained with a 1 × 2 mm pixel size on a polyacrylamide gel phantom using a clinical 1.5‐T whole body MRI system. Temperatures determined from these images using 1 cm 2 regions of interest were found to be within 0.2° of those recorded from the thermocouples and fiber‐optic probes placed inside the gel. © 1991 Academic Press, Inc.