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Echo‐planar imaging of diffusion and perfusion
Author(s) -
Turner Robert,
Le Bihan Denis,
Scott Chesnicks A.
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910190210
Subject(s) - echo planar imaging , perfusion , imaging phantom , pulsatile flow , nuclear magnetic resonance , diffusion , echo (communications protocol) , biomedical engineering , diffusion imaging , nuclear medicine , magnetic resonance imaging , materials science , diffusion mri , computer science , medicine , physics , radiology , cardiology , computer network , thermodynamics
Use of the Stejskal‐Tanner sequence for performing diffusion images in the human brain tends to be complicated by the presence of artifacts caused by voluntary or involuntary, sometimes pulsatile, motion. We describe the implementation of the technique of echo‐planar diffusion imaging, which avoids these artifacts and allows reproducible quantitative values of the diffusion coefficient to be measured in vivo . The effects of perfusion are easily visible in a phantom containing a gel. The results for human brain show a significant “perfusion fraction” in grey matter, consistent with an extracellular, possibly microvascular, volume of about 10%. © 1991 Academic Press, Inc.