In vivo  measurements of bone marrow cellularity using volume‐localized proton NMR spectroscopy | Zendy

Ballon D. | Zendy; Jakubowski A. | Zendy; Gabrilove J. | Zendy; Graham M. C. | Zendy; Zakowski M. | Zendy; Sheridan C. | Zendy; Koutcher J. A. | Zendy

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In vivo measurements of bone marrow cellularity using volume‐localized proton NMR spectroscopy

Author(s) -

Ballon D.,

Jakubowski A.,

Gabrilove J.,

Graham M. C.,

Zakowski M.,

Sheridan C.,

Koutcher J. A.

Publication year - 1991

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910190108

Subject(s) - bone marrow , in vivo , nuclear magnetic resonance spectroscopy , nuclear medicine , pathology , chemistry , medicine , nuclear magnetic resonance , biology , physics , microbiology and biotechnology , organic chemistry

Volume‐localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a total of 25 measurements. These data were compared to cellularity assessments derived from conventional bone marrow core biopsies obtained within a 24‐h period before or after the NMR exam. The results obtained by the two methods are well correlated ( R = 0.94, P < 0.001), suggesting that this noninvasive technique may preclude the need for biopsies in some cases. © 1991 Academic Press, Inc.

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