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In vivo measurements of bone marrow cellularity using volume‐localized proton NMR spectroscopy
Author(s) -
Ballon D.,
Jakubowski A.,
Gabrilove J.,
Graham M. C.,
Zakowski M.,
Sheridan C.,
Koutcher J. A.
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910190108
Subject(s) - bone marrow , in vivo , nuclear magnetic resonance spectroscopy , nuclear medicine , pathology , chemistry , medicine , nuclear magnetic resonance , biology , physics , microbiology and biotechnology , organic chemistry
Volume‐localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a total of 25 measurements. These data were compared to cellularity assessments derived from conventional bone marrow core biopsies obtained within a 24‐h period before or after the NMR exam. The results obtained by the two methods are well correlated ( R = 0.94, P < 0.001), suggesting that this noninvasive technique may preclude the need for biopsies in some cases. © 1991 Academic Press, Inc.