Premium
The effect of chlorpromazine and methylprednisolone on NMR relaxation times in the normal cat brain
Author(s) -
Barnes D.,
Harvey I.,
McDonald W. I.,
Ron M. A.,
Moore S.
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910180124
Subject(s) - chlorpromazine , methylprednisolone , nuclear magnetic resonance , relaxation (psychology) , medicine , chemistry , pharmacology , physics
This small experimental study describes the effects on the NMR relaxation times in normal cat brain of a 5‐day course of high dose methylprednisolone and, separately, a 1‐month course of standard dose daily chlorpromazine. Methylprednisolone had no influence on T 1 or T 2 in these tissues, but chlorpromazine produced a transient fall of T 1 of thalamus, and rise in T 2 of white matter: both normalize after 4 weeks. The mechanism of these changes is unknown. It is concluded that these drugs should not interfere with the quantitative MRI monitoring of brain abnormalities in patients receiving them, although the unlikely occurrence of longer term effects of chlorpromazine has not been excluded. © 1991 Academic Press. Inc.